Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8427

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.31, p 0.414). This receipt's hash covers every field on it, plus the hash of receipt 8426, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8427
    24 Oct 2026, 07:45 UTC

    ENPP4

    dopamine neurons, braak

    predictionENPP4 in dopamine neurons tracks Braak Lewy-body stage

    registereda937ae6687b44ad8

    discovery+0.31 p=0.414 n=9

    replication+0.71 p=0.032 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.31, p 0.414)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    dc31bdbc68a1788dabed4592…
    follows aa2fd0522be5…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8427: ENPP4 in dopamine neurons, braak

power
full sample +0.59 (p 0.011, n 18), 95% CI +0.16 to +0.83. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.56 (p 0.015, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.51 (p 0.030, n 18). not the mix.
skeptic
leave-one-out range +0.54 to +0.71, sign flips 0; without severely affected donors +0.59 (p 0.011, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ENPP4 in dopamine neurons.

case closed: nothing better to follow up.