parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in salivary duct cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 8419

receipt 8427: ENPP4 in dopamine neurons, braak

power: full sample +0.59 (p 0.011, n 18), 95% CI +0.16 to +0.83. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.56 (p 0.015, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.51 (p 0.030, n 18). not the mix.
skeptic: leave-one-out range +0.54 to +0.71, sign flips 0; without severely affected donors +0.59 (p 0.011, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ENPP4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 8426: ENPP4 in oligodendrocytes, braak

power: full sample +0.43 (p 0.074, n 18), 95% CI -0.04 to +0.75. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.39 (p 0.111, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.35 (p 0.156, n 18). could be the mix.
skeptic: leave-one-out range +0.39 to +0.65, sign flips 0; without severely affected donors +0.43 (p 0.074, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ENPP4 in oligodendrocytes.

case closed: nothing better to follow up.

loading the receipts