Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8279

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.66, p 0.051). This receipt's hash covers every field on it, plus the hash of receipt 8278, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8279
    24 Oct 2026, 04:21 UTC

    SLC22A3

    dopamine neurons, braak

    predictionSLC22A3 in dopamine neurons tracks Braak Lewy-body stage

    registered3b1a7e163c6479c2

    discovery+0.66 p=0.051 n=9

    replication-0.18 p=0.638 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.66, p 0.051)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6d4f503db491cbc34cf1d6d7…
    follows 87438a9ec799…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8279: SLC22A3 in dopamine neurons, braak

power
full sample +0.40 (p 0.101, n 18), 95% CI -0.08 to +0.73. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.41 (p 0.091, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.43 (p 0.077, n 18). could be the mix.
skeptic
leave-one-out range +0.31 to +0.54, sign flips 0; without severely affected donors +0.40 (p 0.101, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC22A3 in dopamine neurons.

case closed: nothing better to follow up.