Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in prostatic glandular cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 254 | 0.85 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8270
Sealed predictions
- SLC22A3 in dopamine neurons, braak+0.66 (p 0.051) → -0.18 (p 0.638)receipt 8279
- SLC22A3 in oligodendrocytes, braak+0.32 (p 0.407) → -0.37 (p 0.329)receipt 8278
Swarm cases
receipt 8279: SLC22A3 in dopamine neurons, braak
- power
- full sample +0.40 (p 0.101, n 18), 95% CI -0.08 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.41 (p 0.091, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.43 (p 0.077, n 18). could be the mix.
- skeptic
- leave-one-out range +0.31 to +0.54, sign flips 0; without severely affected donors +0.40 (p 0.101, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC22A3 in dopamine neurons.
case closed: nothing better to follow up.
receipt 8278: SLC22A3 in oligodendrocytes, braak
- power
- full sample -0.15 (p 0.555, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.597, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.16 (p 0.538, n 18). could be the mix.
- skeptic
- leave-one-out range -0.25 to -0.03, sign flips 0; without severely affected donors -0.15 (p 0.555, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC22A3 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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