Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0075

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.09, p 0.583). This receipt's hash covers every field on it, plus the hash of receipt 74, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0075
    16 Oct 2026, 15:58 UTC

    BCHE

    oligodendrocytes, braak

    predictionBCHE in oligodendrocytes tracks Braak Lewy-body stage

    registereda25ce28a89fe0185

    discovery-0.09 p=0.583 n=42

    replication-0.13 p=0.428 n=42

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.09, p 0.583)

    datasimulated substantia nigra cohort (84 donors)

    NO EFFECT

    705ff7cd0a811ba2a49341d9…
    follows 73fa54d5d264…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0075: BCHE in oligodendrocytes, braak

power
full sample -0.08 (p 0.443, n 84), 95% CI -0.29 to +0.13. the interval sits on zero: probably nothing there.
confounder
adjusted for age, sex and PMI: -0.00 (p 0.992, n 84). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.09 (p 0.422); controlling for it: -0.00 (p 0.982, n 84). could be the mix.
skeptic
leave-one-out range -0.12 to -0.06, sign flips 0; without severely affected donors -0.03 (p 0.812, n 75). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for BCHE in oligodendrocytes.

case closed: nothing better to follow up.