Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0647

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.14, p 0.725). This receipt's hash covers every field on it, plus the hash of receipt 646, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0647
    17 Oct 2026, 03:20 UTC

    MTMR10

    dopamine neurons, braak

    predictionMTMR10 in dopamine neurons tracks Braak Lewy-body stage

    registered5489f2370d4557eb

    discovery+0.14 p=0.725 n=9

    replication+0.49 p=0.183 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.14, p 0.725)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2b751d5d43b88498e0fc60da…
    follows c531e35f5c3b…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0647: MTMR10 in dopamine neurons, braak

power
full sample +0.20 (p 0.418, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.21 (p 0.393, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.413, n 18). could be the mix.
skeptic
leave-one-out range +0.10 to +0.35, sign flips 0; without severely affected donors +0.20 (p 0.418, n 18). fragile.
cell type
strongest in oligodendrocytes: +0.60 (p 0.0083, n 18) vs +0.20 in dopamine neurons. proposing oligodendrocytes.
axis
no measure beats "tracks Braak Lewy-body stage" for MTMR10 in dopamine neurons.

case closed: every proposal failed a challenge.