Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5545

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.05, p 0.893). This receipt's hash covers every field on it, plus the hash of receipt 5544, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5545
    21 Oct 2026, 17:28 UTC

    RUNX2

    microglia, braak

    predictionRUNX2 in microglia tracks Braak Lewy-body stage

    registered722030b4c3ce7d96

    discovery-0.05 p=0.893 n=9

    replication+0.92 p=4.0e-4 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.05, p 0.893)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3c191d6493721bf0085df2c2…
    follows f1388b8117a9…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5545: RUNX2 in microglia, braak

power
full sample +0.41 (p 0.089, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.41 (p 0.089, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.40 (p 0.097, n 18). could be the mix.
skeptic
leave-one-out range +0.37 to +0.62, sign flips 0; without severely affected donors +0.41 (p 0.089, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RUNX2 in microglia.

case closed: nothing better to follow up.