parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in innate lymphoid cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	5 Parkinson's papers of 13,034	0.76
pathways Reactome	9 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 5538

receipt 5546: RUNX2 in dopamine neurons, braak

power: full sample -0.08 (p 0.767, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.08 (p 0.767, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.27 (p 0.273, n 18). could be the mix.
skeptic: leave-one-out range -0.22 to +0.05, sign flips 3; without severely affected donors -0.08 (p 0.767, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RUNX2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5545: RUNX2 in microglia, braak

power: full sample +0.41 (p 0.089, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.41 (p 0.089, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.40 (p 0.097, n 18). could be the mix.
skeptic: leave-one-out range +0.37 to +0.62, sign flips 0; without severely affected donors +0.41 (p 0.089, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RUNX2 in microglia.

case closed: nothing better to follow up.

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