Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0523

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.35, p 0.360). This receipt's hash covers every field on it, plus the hash of receipt 522, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0523
    17 Oct 2026, 02:30 UTC

    VPS13C

    dopamine neurons, braak

    predictionVPS13C in dopamine neurons tracks Braak Lewy-body stage

    registered567c5a6d16f3801b

    discovery+0.35 p=0.360 n=9

    replication+0.03 p=0.946 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.35, p 0.360)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a48fa325581b8b111500be6f…
    follows 56955110bf9c…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0523: VPS13C in dopamine neurons, braak

power
full sample +0.19 (p 0.444, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.25 (p 0.315, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.148, n 18). could be the mix.
skeptic
leave-one-out range +0.09 to +0.33, sign flips 0; without severely affected donors +0.19 (p 0.444, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for VPS13C in dopamine neurons.

case closed: nothing better to follow up.