Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.82 (overall 0.73) | 0.82 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 81 Parkinson's papers of 137 | 0.42 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 11444
Earlier readings: 2026-10-26 0.49; 2026-10-25 0.49; 2026-10-24 0.49; 2026-10-23 0.49.
Sealed predictions
- VPS13C in dopamine neurons, braak-0.38 (p 0.013) → -0.47 (p 0.002)held
- VPS13C in dopamine neurons, braak+0.35 (p 0.360) → +0.03 (p 0.946)receipt 0523
- VPS13C in dopamine neurons, resilience+0.28 (p 0.317) → -0.08 (p 0.788)receipt 0028
In the sealed studies
- The lysosomal axis in dopamine neurons: did not hold
Swarm cases
receipt 0523: VPS13C in dopamine neurons, braak
- power
- full sample +0.19 (p 0.444, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.25 (p 0.315, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.148, n 18). could be the mix.
- skeptic
- leave-one-out range +0.09 to +0.33, sign flips 0; without severely affected donors +0.19 (p 0.444, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for VPS13C in dopamine neurons.
case closed: nothing better to follow up.
receipt 0028: VPS13C in dopamine neurons, resilience
- power
- full sample +0.15 (p 0.449, n 55), 95% CI -0.12 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for age, sex and PMI: +0.17 (p 0.400, n 55). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: +0.06 (p 0.768, n 55). could be the mix.
- skeptic
- leave-one-out range +0.08 to +0.25, sign flips 0; without severely affected donors +0.19 (p 0.334, n 46). fragile.
- cell type
- no other cell group does better.
- axis
- nigra beats resilience for VPS13C in dopamine neurons: -0.49 (p 2.1e-6, n 84). proposing nigra.
case closed: every proposal failed a challenge.
Receipts
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