Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4449

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.17, p 0.663). This receipt's hash covers every field on it, plus the hash of receipt 4448, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4449
    20 Oct 2026, 17:45 UTC

    P2RX7

    dopamine neurons, braak

    predictionP2RX7 in dopamine neurons tracks Braak Lewy-body stage

    registeredd45c507d508ca53b

    discovery+0.17 p=0.663 n=9

    replication+0.15 p=0.699 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.17, p 0.663)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d0daedf302906b188c07ea94…
    follows 85ebdeb6eaad…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4449: P2RX7 in dopamine neurons, braak

power
full sample +0.18 (p 0.476, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.18 (p 0.476, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.487, n 18). could be the mix.
skeptic
leave-one-out range +0.11 to +0.35, sign flips 0; without severely affected donors +0.18 (p 0.476, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for P2RX7 in dopamine neurons.

case closed: nothing better to follow up.