Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4348

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.58, p 0.102). This receipt's hash covers every field on it, plus the hash of receipt 4347, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4348
    20 Oct 2026, 15:30 UTC

    IL2

    dopamine neurons, braak

    predictionIL2 in dopamine neurons tracks Braak Lewy-body stage

    registeredc7f0d9e764ae77c2

    discovery+0.58 p=0.102 n=9

    replication+0.28 p=0.459 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.58, p 0.102)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2cdc85a2c4bda31de927b4f3…
    follows f8ecff31a2e9…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4348: IL2 in dopamine neurons, braak

power
full sample +0.46 (p 0.052, n 18), 95% CI -0.00 to +0.77. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.48 (p 0.046, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.50 (p 0.036, n 18). not the mix.
skeptic
leave-one-out range +0.41 to +0.68, sign flips 0; without severely affected donors +0.46 (p 0.052, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IL2 in dopamine neurons.

case closed: nothing better to follow up.