Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2373

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.11, p 0.785). This receipt's hash covers every field on it, plus the hash of receipt 2372, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2373
    18 Oct 2026, 20:38 UTC

    SIGMAR1

    dopamine neurons, braak

    predictionSIGMAR1 in dopamine neurons tracks Braak Lewy-body stage

    registered291648ab7ffb95d6

    discovery-0.11 p=0.785 n=9

    replication-0.36 p=0.347 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.11, p 0.785)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f8416f81f9053931a66a3c9c…
    follows d5643b7faa62…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2373: SIGMAR1 in dopamine neurons, braak

power
full sample -0.28 (p 0.261, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.29 (p 0.243, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.25 (p 0.310, n 18). could be the mix.
skeptic
leave-one-out range -0.38 to -0.18, sign flips 0; without severely affected donors -0.28 (p 0.261, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SIGMAR1 in dopamine neurons.

case closed: nothing better to follow up.