Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.12 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: dextromethorphan, fenfluramine, dextromethorphan hydrobromide +6 | 1.00 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 1 stopped | 0.84 |
| literature PubMed | 6 Parkinson's papers of 223 | 0.74 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2366
Sealed predictions
- SIGMAR1 in dopamine neurons, braak-0.11 (p 0.785) → -0.36 (p 0.347)receipt 2373
Swarm cases
receipt 2373: SIGMAR1 in dopamine neurons, braak
- power
- full sample -0.28 (p 0.261, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.29 (p 0.243, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.25 (p 0.310, n 18). could be the mix.
- skeptic
- leave-one-out range -0.38 to -0.18, sign flips 0; without severely affected donors -0.28 (p 0.261, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SIGMAR1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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