Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2244

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.54, p 0.133). This receipt's hash covers every field on it, plus the hash of receipt 2243, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2244
    18 Oct 2026, 17:36 UTC

    PLEKHM1

    oligodendrocytes, braak

    predictionPLEKHM1 in oligodendrocytes tracks Braak Lewy-body stage

    registeredf1dd92d5986667f6

    discovery-0.54 p=0.133 n=9

    replication-0.32 p=0.407 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.54, p 0.133)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    71a6688066c0720e3f256b22…
    follows 030a630aa198…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2244: PLEKHM1 in oligodendrocytes, braak

power
full sample -0.51 (p 0.031, n 18), 95% CI -0.79 to -0.05. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.55 (p 0.018, n 18). holds up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.57 (p 0.014, n 18). not the mix.
skeptic
leave-one-out range -0.61 to -0.44, sign flips 0; without severely affected donors -0.51 (p 0.031, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLEKHM1 in oligodendrocytes.

case closed: nothing better to follow up.