Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0199

A sealed prediction that did not hold.

did not replicate (discovery +0.71 p 0.032; held-out -0.23 p 0.549). This receipt's hash covers every field on it, plus the hash of receipt 198, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0199
    16 Oct 2026, 18:53 UTC

    SCN10A

    dopamine neurons, braak

    predictionSCN10A in dopamine neurons tracks Braak Lewy-body stage

    registered207dd5f3406b3e40

    discovery+0.71 p=0.032 n=9

    replication-0.23 p=0.549 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.71 p 0.032; held-out -0.23 p 0.549)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    7b4f3b327ae327b83a9e4f6b…
    follows 9f8728722bea…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0199: SCN10A in dopamine neurons, braak

power
full sample +0.16 (p 0.515, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.15 (p 0.555, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.15 (p 0.549, n 18). could be the mix.
skeptic
leave-one-out range +0.07 to +0.31, sign flips 0; without severely affected donors +0.16 (p 0.515, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SCN10A in dopamine neurons.

case closed: nothing better to follow up.