Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10923

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.58, p 0.102). This receipt's hash covers every field on it, plus the hash of receipt 10922, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10923
    26 Oct 2026, 14:26 UTC

    ALOX5

    dopamine neurons, braak

    predictionALOX5 in dopamine neurons tracks Braak Lewy-body stage

    registered5890675054f3af9e

    discovery-0.58 p=0.102 n=9

    replication-0.16 p=0.685 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.58, p 0.102)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    cd354120eb21aa309fa993b0…
    follows e79adeb893de…

Covered by the on-chain checkpoint of receipt 10945 (2026-10-26 14:53 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10923: ALOX5 in dopamine neurons, braak

power
full sample -0.33 (p 0.179, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.34 (p 0.161, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.42 (p 0.086, n 18). could be the mix.
skeptic
leave-one-out range -0.48 to -0.25, sign flips 0; without severely affected donors -0.33 (p 0.179, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ALOX5 in dopamine neurons.

case closed: nothing better to follow up.