Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in hepatocytes | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 154 | 0.85 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3372
Sealed predictions
- TTPA in dopamine neurons, braak+0.82 (p 0.007) → +0.47 (p 0.197)receipt 3380
- TTPA in astrocytes, braak-0.19 (p 0.631) → +0.11 (p 0.787)receipt 3379
Swarm cases
receipt 3380: TTPA in dopamine neurons, braak
- power
- full sample +0.66 (p 0.0026, n 18), 95% CI +0.29 to +0.86. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.67 (p 0.0024, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.69 (p 0.0014, n 18). not the mix.
- skeptic
- leave-one-out range +0.62 to +0.75, sign flips 0; without severely affected donors +0.66 (p 0.0026, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TTPA in dopamine neurons.
case closed: nothing better to follow up.
receipt 3379: TTPA in astrocytes, braak
- power
- full sample +0.16 (p 0.532, n 18), 95% CI -0.33 to +0.58. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.20 (p 0.434, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.20 (p 0.434, n 18). could be the mix.
- skeptic
- leave-one-out range +0.05 to +0.27, sign flips 0; without severely affected donors +0.16 (p 0.532, n 18). fragile.
- cell type
- strongest in dopamine neurons: +0.66 (p 0.0026, n 18) vs +0.16 in astrocytes. proposing dopamine neurons.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TTPA in astrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TTPA · dopamine neurons · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.43 p 0.131 (needs p < 5.5e-4)
Receipts
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