parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.09 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in pituitary stem cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	6 Parkinson's papers of 68	0.74
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 2958

receipt 2967: TENM4 in dopamine neurons, braak

power: full sample -0.25 (p 0.319, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.26 (p 0.306, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.49 (p 0.039, n 18). not the mix.
skeptic: leave-one-out range -0.39 to -0.15, sign flips 0; without severely affected donors -0.25 (p 0.319, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TENM4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2966: TENM4 in microglia, braak

power: full sample -0.19 (p 0.450, n 18), 95% CI -0.60 to +0.30. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.21 (p 0.403, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.21 (p 0.403, n 18). could be the mix.
skeptic: leave-one-out range -0.36 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.450, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TENM4 in microglia.

case closed: nothing better to follow up.

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