Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.20 (overall 0.16) | 0.20 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.24 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 68 Parkinson's papers of 922 | 0.44 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2170
Sealed predictions
- TARDBP in dopamine neurons, braak-0.33 (p 0.389) → +0.38 (p 0.309)receipt 2175
Swarm cases
receipt 2175: TARDBP in dopamine neurons, braak
- power
- full sample +0.01 (p 0.969, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.969, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.874, n 18). could be the mix.
- skeptic
- leave-one-out range -0.12 to +0.14, sign flips 11; without severely affected donors +0.01 (p 0.969, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TARDBP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts