Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in microglia (127 nCPM) | 1.00 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 17 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 6258
Sealed predictions
- SYT6 in dopamine neurons, braak-0.68 (p 0.045) → -0.53 (p 0.145)receipt 6267
- SYT6 in microglia, braak+0.13 (p 0.739) → -0.53 (p 0.146)receipt 6266
Swarm cases
receipt 6267: SYT6 in dopamine neurons, braak
- power
- full sample -0.66 (p 0.0031, n 18), 95% CI -0.86 to -0.27. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.64 (p 0.0039, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.78 (p 1.4e-4, n 18). not the mix.
- skeptic
- leave-one-out range -0.76 to -0.61, sign flips 0; without severely affected donors -0.66 (p 0.0031, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SYT6 in dopamine neurons.
case closed: nothing better to follow up.
receipt 6266: SYT6 in microglia, braak
- power
- full sample -0.23 (p 0.365, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.19 (p 0.455, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.19 (p 0.444, n 18). could be the mix.
- skeptic
- leave-one-out range -0.39 to -0.14, sign flips 0; without severely affected donors -0.23 (p 0.365, n 18). fragile.
- cell type
- strongest in dopamine neurons: -0.66 (p 0.0031, n 18) vs -0.23 in microglia. proposing dopamine neurons.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SYT6 in microglia.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SYT6 · dopamine neurons · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.18 p 0.534 (needs p < 3.2e-4)
Receipts
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