Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ST8SIA1

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

translation score 0.50, read 2026-10-28; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocyte progenitor cells; strongest in bergmann glia0.75
chemistry
Open Targets		reachable by antibody0.36
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		3 Parkinson's papers of 1060.82
pathways
Reactome		1 pathway; mostly energy0.60

No case: the score is under the bar. Receipt 12503

Sealed predictions

  1. ST8SIA1 in dopamine neurons, braak+0.05 (p 0.907) → +0.24 (p 0.535)receipt 12512
  2. ST8SIA1 in oligodendrocytes, braak+0.37 (p 0.329) → -0.34 (p 0.378)receipt 12511

Swarm cases

receipt 12512: ST8SIA1 in dopamine neurons, braak

power
full sample +0.21 (p 0.398, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.17 (p 0.498, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.398, n 18). could be the mix.
skeptic
leave-one-out range +0.09 to +0.34, sign flips 0; without severely affected donors +0.21 (p 0.398, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ST8SIA1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12511: ST8SIA1 in oligodendrocytes, braak

power
full sample +0.04 (p 0.874, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.06 (p 0.827, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.06 (p 0.827, n 18). could be the mix.
skeptic
leave-one-out range -0.08 to +0.16, sign flips 6; without severely affected donors +0.04 (p 0.874, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ST8SIA1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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