Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.03 (overall 0.02) | 0.03 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in late primary spermatocytes | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 7670
Sealed predictions
- SPATA22 in oligodendrocytes, braak+0.52 (p 0.150) → -0.66 (p 0.054)receipt 7677
- SPATA22 in dopamine neurons, braak-0.16 (p 0.689) → +0.03 (p 0.946)receipt 7678
Swarm cases
receipt 7678: SPATA22 in dopamine neurons, braak
- power
- full sample -0.02 (p 0.942, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.05 (p 0.840, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.787, n 18). could be the mix.
- skeptic
- leave-one-out range -0.12 to +0.10, sign flips 7; without severely affected donors -0.02 (p 0.942, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SPATA22 in dopamine neurons.
case closed: nothing better to follow up.
receipt 7677: SPATA22 in oligodendrocytes, braak
- power
- full sample -0.10 (p 0.702, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.17 (p 0.504, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.25 (p 0.323, n 18). could be the mix.
- skeptic
- leave-one-out range -0.21 to +0.04, sign flips 3; without severely affected donors -0.10 (p 0.702, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SPATA22 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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