Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched in brain excitatory neurons (72 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 35 Parkinson's papers of 65 | 0.53 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8224
Sealed predictions
- SNCB in dopamine neurons, braak-0.37 (p 0.329) → -0.37 (p 0.329)receipt 8232
Swarm cases
receipt 8232: SNCB in dopamine neurons, braak
- power
- full sample -0.42 (p 0.082, n 18), 95% CI -0.74 to +0.06. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.45 (p 0.063, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.60 (p 0.0086, n 18). not the mix.
- skeptic
- leave-one-out range -0.58 to -0.34, sign flips 0; without severely affected donors -0.42 (p 0.082, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SNCB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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