parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.07 from other evidence	0.00
cell type Human Protein Atlas	group enriched in astrocytes (59 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 51	0.91
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 3892

SLC7A10 in dopamine neurons, braak+0.25 (p 0.520) → -0.54 (p 0.130)receipt 3900
SLC7A10 in astrocytes, braak-0.46 (p 0.214) → +0.32 (p 0.400)receipt 3899

receipt 3900: SLC7A10 in dopamine neurons, braak

power: full sample -0.19 (p 0.439, n 18), 95% CI -0.61 to +0.30. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.22 (p 0.379, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.33 (p 0.185, n 18). could be the mix.
skeptic: leave-one-out range -0.32 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.439, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SLC7A10 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3899: SLC7A10 in astrocytes, braak

power: full sample +0.02 (p 0.949, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.07 (p 0.787, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.07 (p 0.787, n 18). could be the mix.
skeptic: leave-one-out range -0.12 to +0.11, sign flips 6; without severely affected donors +0.02 (p 0.949, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SLC7A10 in astrocytes.

case closed: nothing better to follow up.

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