Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 576 | 0.91 |
| pathways Reactome | 6 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3192
Sealed predictions
- SLC1A5 in dopamine neurons, braak-0.65 (p 0.058) → +0.52 (p 0.154)receipt 3198
Swarm cases
receipt 3198: SLC1A5 in dopamine neurons, braak
- power
- full sample -0.04 (p 0.861, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.03 (p 0.894, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.928, n 18). could be the mix.
- skeptic
- leave-one-out range -0.20 to +0.09, sign flips 4; without severely affected donors -0.04 (p 0.861, n 18). fragile.
- cell type
- strongest in microglia: -0.61 (p 0.0067, n 18) vs -0.04 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC1A5 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SLC1A5 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.27 p 0.328 (needs p < 6.0e-4)
Receipts
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