parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in extravillous trophoblasts	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 276	0.91
pathways Reactome	4 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 10457

SERPINE2 in dopamine neurons, braak-0.49 (p 0.183) → +0.27 (p 0.489)receipt 10465
SERPINE2 in astrocytes, braak+0.35 (p 0.355) → +0.10 (p 0.807)receipt 10464

receipt 10465: SERPINE2 in dopamine neurons, braak

power: full sample -0.37 (p 0.130, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.40 (p 0.099, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.089, n 18). could be the mix.
skeptic: leave-one-out range -0.49 to -0.28, sign flips 0; without severely affected donors -0.37 (p 0.130, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SERPINE2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 10464: SERPINE2 in astrocytes, braak

power: full sample +0.20 (p 0.418, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.20 (p 0.418, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.26 (p 0.302, n 18). could be the mix.
skeptic: leave-one-out range +0.10 to +0.29, sign flips 0; without severely affected donors +0.20 (p 0.418, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SERPINE2 in astrocytes.

case closed: nothing better to follow up.

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