Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in rod photoreceptor cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 39 | 0.79 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 7935
Sealed predictions
- SCAMP5 in dopamine neurons, braak-0.68 (p 0.042) → -0.40 (p 0.291)receipt 7942
Swarm cases
receipt 7942: SCAMP5 in dopamine neurons, braak
- power
- full sample -0.33 (p 0.182, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.32 (p 0.194, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.067, n 18). could be the mix.
- skeptic
- leave-one-out range -0.44 to -0.24, sign flips 0; without severely affected donors -0.33 (p 0.182, n 18). fragile.
- cell type
- strongest in OPCs: -0.61 (p 0.0075, n 18) vs -0.33 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SCAMP5 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SCAMP5 · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.47 p 0.091 (needs p < 2.7e-4)
Receipts
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