parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.30 (overall 0.19)	0.30
cell type Human Protein Atlas	cell type enhanced in astrocytes (1453 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 111	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 2068

receipt 2075: RBMS3 in dopamine neurons, braak

power: full sample +0.46 (p 0.055, n 18), 95% CI -0.01 to +0.76. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.45 (p 0.062, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.46 (p 0.054, n 18). could be the mix.
skeptic: leave-one-out range +0.39 to +0.59, sign flips 0; without severely affected donors +0.46 (p 0.055, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RBMS3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2074: RBMS3 in astrocytes, braak

power: full sample -0.01 (p 0.962, n 18), 95% CI -0.48 to +0.46. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.03 (p 0.901, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.06 (p 0.807, n 18). could be the mix.
skeptic: leave-one-out range -0.16 to +0.13, sign flips 10; without severely affected donors -0.01 (p 0.962, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RBMS3 in astrocytes.

case closed: nothing better to follow up.

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