Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.27 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in loop of henle epithelial cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1502
Sealed predictions
- PPP1R3B in microglia, braak+0.40 (p 0.292) → -0.05 (p 0.893)receipt 1507
- PPP1R3B in dopamine neurons, braak-0.69 (p 0.039) → -0.39 (p 0.298)receipt 1508
Swarm cases
receipt 1508: PPP1R3B in dopamine neurons, braak
- power
- full sample -0.47 (p 0.050, n 18), 95% CI -0.77 to -0.00. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.47 (p 0.051, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.066, n 18). could be the mix.
- skeptic
- leave-one-out range -0.63 to -0.40, sign flips 0; without severely affected donors -0.47 (p 0.050, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPP1R3B in dopamine neurons.
case closed: nothing better to follow up.
receipt 1507: PPP1R3B in microglia, braak
- power
- full sample +0.08 (p 0.748, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.754, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.27 (p 0.273, n 18). could be the mix.
- skeptic
- leave-one-out range -0.02 to +0.24, sign flips 2; without severely affected donors +0.08 (p 0.748, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPP1R3B in microglia.
case closed: nothing better to follow up.
Receipts
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