Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 183 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7393
Sealed predictions
- PPP1R15A in dopamine neurons, braak-0.42 (p 0.262) → -0.70 (p 0.034)receipt 7401
Swarm cases
receipt 7401: PPP1R15A in dopamine neurons, braak
- power
- full sample -0.51 (p 0.032, n 18), 95% CI -0.79 to -0.05. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.44 (p 0.071, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.055, n 18). could be the mix.
- skeptic
- leave-one-out range -0.57 to -0.45, sign flips 0; without severely affected donors -0.51 (p 0.032, n 18). robust.
- cell type
- strongest in oligodendrocytes: -0.71 (p 0.0011, n 18) vs -0.51 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPP1R15A in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PPP1R15A · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.52 p 0.062 (needs p < 2.9e-4)
Receipts
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