Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.18 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 2,463 | 0.71 |
| pathways Reactome | 3 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 2099
Sealed predictions
- PIEZO1 in dopamine neurons, braak-0.11 (p 0.773) → -0.55 (p 0.123)receipt 2106
Swarm cases
receipt 2106: PIEZO1 in dopamine neurons, braak
- power
- full sample -0.43 (p 0.072, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.47 (p 0.049, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.64 (p 0.0040, n 18). not the mix.
- skeptic
- leave-one-out range -0.56 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.072, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PIEZO1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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