Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 53 | 0.91 |
| pathways Reactome | 3 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 3272
Sealed predictions
- PI4K2A in dopamine neurons, braak+0.36 (p 0.336) → -0.18 (p 0.646)receipt 3280
Swarm cases
receipt 3280: PI4K2A in dopamine neurons, braak
- power
- full sample +0.10 (p 0.702, n 18), 95% CI -0.39 to +0.54. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.05 (p 0.847, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.02 (p 0.928, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.21, sign flips 1; without severely affected donors +0.10 (p 0.702, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.67 (p 0.0025, n 18) vs +0.10 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PI4K2A in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PI4K2A · oligodendrocytes · braak: substantia nigra, an independent cohort: not measured
Receipts
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