Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 85 Parkinson's papers of 18,246 | 0.41 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2841
Sealed predictions
- PGP in dopamine neurons, braak+0.09 (p 0.814) → +0.45 (p 0.219)receipt 2848
Swarm cases
receipt 2848: PGP in dopamine neurons, braak
- power
- full sample +0.41 (p 0.091, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.47 (p 0.050, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.50 (p 0.033, n 18). not the mix.
- skeptic
- leave-one-out range +0.34 to +0.52, sign flips 0; without severely affected donors +0.41 (p 0.091, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PGP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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