Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PDZRN4

PDZ domain containing ring finger 4

translation score 0.49, read 2026-10-18; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		genetic association 0.25 (overall 0.15)0.25
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocyte progenitor cells; strongest in peritubular myoid cells0.75
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 2181

Sealed predictions

  1. PDZRN4 in dopamine neurons, braak+0.69 (p 0.042) → +0.54 (p 0.137)receipt 2189
  2. PDZRN4 in oligodendrocytes, braak-0.46 (p 0.209) → +0.16 (p 0.689)receipt 2188

Swarm cases

receipt 2189: PDZRN4 in dopamine neurons, braak

power
full sample +0.34 (p 0.173, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.34 (p 0.173, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.33 (p 0.176, n 18). could be the mix.
skeptic
leave-one-out range +0.24 to +0.46, sign flips 0; without severely affected donors +0.34 (p 0.173, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDZRN4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2188: PDZRN4 in oligodendrocytes, braak

power
full sample -0.08 (p 0.767, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.01 (p 0.969, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.10 (p 0.683, n 18). could be the mix.
skeptic
leave-one-out range -0.21 to +0.03, sign flips 3; without severely affected donors -0.08 (p 0.767, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDZRN4 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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