parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in astrocytes (193 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 316	0.82
pathways Reactome	8 pathways; mostly protein handling	0.90

No case: the score is under the bar. Receipt 12266

PABPN1 in dopamine neurons, braak+0.14 (p 0.718) → -0.32 (p 0.407)receipt 12273
PABPN1 in astrocytes, braak-0.11 (p 0.773) → -0.02 (p 0.964)receipt 12272

receipt 12273: PABPN1 in dopamine neurons, braak

power: full sample -0.13 (p 0.621, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.21 (p 0.413, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.28 (p 0.254, n 18). could be the mix.
skeptic: leave-one-out range -0.27 to -0.02, sign flips 0; without severely affected donors -0.13 (p 0.621, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PABPN1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12272: PABPN1 in astrocytes, braak

power: full sample -0.03 (p 0.915, n 18), 95% CI -0.49 to +0.45. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.03 (p 0.901, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.05 (p 0.840, n 18). could be the mix.
skeptic: leave-one-out range -0.17 to +0.08, sign flips 8; without severely affected donors -0.03 (p 0.915, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PABPN1 in astrocytes.

case closed: nothing better to follow up.

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