Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in pituitary stem cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 424 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4338
Sealed predictions
- NFIA in dopamine neurons, braak-0.28 (p 0.471) → -0.11 (p 0.773)receipt 4346
- NFIA in astrocytes, braak+0.16 (p 0.685) → +0.37 (p 0.323)receipt 4345
Swarm cases
receipt 4346: NFIA in dopamine neurons, braak
- power
- full sample -0.09 (p 0.728, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.11 (p 0.652, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.627, n 18). could be the mix.
- skeptic
- leave-one-out range -0.19 to +0.05, sign flips 3; without severely affected donors -0.09 (p 0.728, n 18). fragile.
- cell type
- strongest in microglia: -0.65 (p 0.0037, n 18) vs -0.09 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NFIA in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up NFIA · microglia · braak: substantia nigra, an independent cohort (already registered)
receipt 4345: NFIA in astrocytes, braak
- power
- full sample +0.40 (p 0.103, n 18), 95% CI -0.09 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.42 (p 0.080, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.50 (p 0.036, n 18). not the mix.
- skeptic
- leave-one-out range +0.33 to +0.55, sign flips 0; without severely affected donors +0.40 (p 0.103, n 18). fragile.
- cell type
- strongest in microglia: -0.65 (p 0.0037, n 18) vs +0.40 in astrocytes. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NFIA in astrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up NFIA · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.00 p 1.000 (needs p < 4.6e-4)
Receipts
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