Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.04 (overall 0.03) | 0.04 |
| cell type Human Protein Atlas | cell type enhanced in other brain neurons (18 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 167 | 0.85 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6766
Sealed predictions
- NEIL2 in dopamine neurons, braak-0.26 (p 0.502) → -0.81 (p 0.008)receipt 6774
Swarm cases
receipt 6774: NEIL2 in dopamine neurons, braak
- power
- full sample -0.54 (p 0.020, n 18), 95% CI -0.81 to -0.10. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.59 (p 0.0096, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.66 (p 0.0031, n 18). not the mix.
- skeptic
- leave-one-out range -0.65 to -0.48, sign flips 0; without severely affected donors -0.54 (p 0.020, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NEIL2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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