Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.05 (overall 0.03) | 0.05 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (extravillous trophoblasts) | 0.10 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 628 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 6454
Sealed predictions
- LIN28B in dopamine neurons, braak+0.25 (p 0.517) → +0.49 (p 0.177)receipt 6460
Swarm cases
receipt 6460: LIN28B in dopamine neurons, braak
- power
- full sample +0.41 (p 0.093, n 18), 95% CI -0.07 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.48 (p 0.044, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.50 (p 0.033, n 18). not the mix.
- skeptic
- leave-one-out range +0.33 to +0.54, sign flips 0; without severely affected donors +0.41 (p 0.093, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LIN28B in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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