Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including other brain neurons; strongest in ocular epithelial cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket: nedosiran sodium | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 15 Parkinson's papers of 3,553 | 0.64 |
| pathways Reactome | 2 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 5779
Sealed predictions
- LDHA in dopamine neurons, braak+0.08 (p 0.838) → +0.05 (p 0.892)receipt 5786
Swarm cases
receipt 5786: LDHA in dopamine neurons, braak
- power
- full sample +0.02 (p 0.928, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.00 (p 0.997, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.02 (p 0.942, n 18). could be the mix.
- skeptic
- leave-one-out range -0.08 to +0.18, sign flips 6; without severely affected donors +0.02 (p 0.928, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LDHA in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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