Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in podocytes | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 18 Parkinson's papers of 1,056 | 0.61 |
| pathways Reactome | 1 pathway; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 10921
Sealed predictions
- HTRA1 in dopamine neurons, braak-0.08 (p 0.838) → +0.25 (p 0.514)receipt 10931
- HTRA1 in oligodendrocytes, braak+0.03 (p 0.944) → -0.11 (p 0.784)receipt 10930
Swarm cases
receipt 10931: HTRA1 in dopamine neurons, braak
- power
- full sample +0.09 (p 0.709, n 18), 95% CI -0.39 to +0.54. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.767, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.08 (p 0.767, n 18). could be the mix.
- skeptic
- leave-one-out range +0.03 to +0.25, sign flips 0; without severely affected donors +0.09 (p 0.709, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HTRA1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 10930: HTRA1 in oligodendrocytes, braak
- power
- full sample +0.04 (p 0.888, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.00 (p 0.997, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.14 (p 0.579, n 18). could be the mix.
- skeptic
- leave-one-out range -0.09 to +0.14, sign flips 4; without severely affected donors +0.04 (p 0.888, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HTRA1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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