Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in late spermatids | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 345 | 0.79 |
| pathways Reactome | 3 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 4150
Sealed predictions
- HIP1 in dopamine neurons, braak-0.75 (p 0.021) → +0.18 (p 0.635)receipt 4158
- HIP1 in oligodendrocytes, braak-0.75 (p 0.019) → -0.01 (p 0.982)receipt 4157
Swarm cases
receipt 4158: HIP1 in dopamine neurons, braak
- power
- full sample -0.29 (p 0.239, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.294, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.31 (p 0.214, n 18). could be the mix.
- skeptic
- leave-one-out range -0.40 to -0.19, sign flips 0; without severely affected donors -0.29 (p 0.239, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HIP1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 4157: HIP1 in oligodendrocytes, braak
- power
- full sample -0.33 (p 0.185, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.28 (p 0.254, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.28 (p 0.261, n 18). could be the mix.
- skeptic
- leave-one-out range -0.52 to -0.25, sign flips 0; without severely affected donors -0.33 (p 0.185, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for HIP1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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