parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in astrocytes (30 nCPM)	1.00
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 10909

HILPDA in astrocytes, braak-0.07 (p 0.849) → -0.03 (p 0.946)receipt 10915
HILPDA in dopamine neurons, braak-0.07 (p 0.856) → +0.32 (p 0.403)receipt 10916

receipt 10916: HILPDA in dopamine neurons, braak

power: full sample +0.11 (p 0.658, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.11 (p 0.677, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.591, n 18). could be the mix.
skeptic: leave-one-out range -0.03 to +0.26, sign flips 2; without severely affected donors +0.11 (p 0.658, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HILPDA in dopamine neurons.

case closed: nothing better to follow up.

receipt 10915: HILPDA in astrocytes, braak

power: full sample +0.18 (p 0.482, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.19 (p 0.444, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.11 (p 0.652, n 18). could be the mix.
skeptic: leave-one-out range +0.11 to +0.34, sign flips 0; without severely affected donors +0.18 (p 0.482, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HILPDA in astrocytes.

case closed: nothing better to follow up.

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