Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

HES5

hes family bHLH transcription factor 5

translation score 0.47, read 2026-10-28; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
group enriched in astrocytes (87 nCPM)1.00
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
7 Parkinson's papers of 6220.73
pathways
Reactome
6 pathways; mostly growth signalling0.60

No case: the score is under the bar. Receipt 12515

Sealed predictions

  1. HES5 in dopamine neurons, braakn/a → n/areceipt 12523
  2. HES5 in astrocytes, braakn/a → n/areceipt 12522

Swarm cases

receipt 12523: HES5 in dopamine neurons, braak

cell type
HES5 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HES5 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12522: HES5 in astrocytes, braak

cell type
HES5 is not measured in astrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HES5 in astrocytes.

case closed: nothing better to follow up.

Receipts

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