parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in colonocytes	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 131	0.91
pathways Reactome	3 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 9800

receipt 9808: HEPH in dopamine neurons, braak

power: full sample +0.48 (p 0.046, n 18), 95% CI +0.01 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.49 (p 0.041, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.49 (p 0.041, n 18). not the mix.
skeptic: leave-one-out range +0.41 to +0.67, sign flips 0; without severely affected donors +0.48 (p 0.046, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HEPH in dopamine neurons.

case closed: nothing better to follow up.

receipt 9807: HEPH in astrocytes, braak

power: full sample -0.33 (p 0.176, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.34 (p 0.161, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.28 (p 0.258, n 18). could be the mix.
skeptic: leave-one-out range -0.46 to -0.25, sign flips 0; without severely affected donors -0.33 (p 0.176, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for HEPH in astrocytes.

case closed: nothing better to follow up.

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