Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

HCN2

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

translation score 0.46, read 2026-10-17; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.34 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in retinal bipolar cells0.75
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		12 Parkinson's papers of 7810.66
pathways
Reactome		1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 0930

Sealed predictions

  1. HCN2 in dopamine neurons, braak-0.65 (p 0.060) → -0.71 (p 0.033)receipt 0938
  2. HCN2 in oligodendrocytes, braak-0.11 (p 0.784) → -0.61 (p 0.083)receipt 0937

Swarm cases

receipt 0938: HCN2 in dopamine neurons, braak

power
full sample -0.44 (p 0.066, n 18), 95% CI -0.75 to +0.03. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.48 (p 0.046, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.027, n 18). not the mix.
skeptic
leave-one-out range -0.54 to -0.37, sign flips 0; without severely affected donors -0.44 (p 0.066, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HCN2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 0937: HCN2 in oligodendrocytes, braak

power
full sample -0.35 (p 0.153, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.38 (p 0.118, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.41 (p 0.093, n 18). could be the mix.
skeptic
leave-one-out range -0.55 to -0.28, sign flips 0; without severely affected donors -0.35 (p 0.153, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HCN2 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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