Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.60 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (respiratory ciliated cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: neboglamine, cns-5161, av-101 +24 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11455
Earlier readings: 2026-10-26 0.47; 2026-10-25 0.47; 2026-10-24 0.47; 2026-10-23 0.47.
Sealed predictions
- GRIN3B in dopamine neurons, braak-0.56 (p 0.116) → -0.63 (p 0.068)receipt 0563
- GRIN3B in dopamine neurons, braak+0.29 (p 0.066) → +0.07 (p 0.661)receipt 0091
- GRIN3B in dopamine neurons, resilience-0.22 (p 0.414) → +0.06 (p 0.834)receipt 0092
Swarm cases
receipt 0563: GRIN3B in dopamine neurons, braak
- power
- full sample -0.60 (p 0.0086, n 18), 95% CI -0.83 to -0.18. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.61 (p 0.0067, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.63 (p 0.0055, n 18). not the mix.
- skeptic
- leave-one-out range -0.70 to -0.55, sign flips 0; without severely affected donors -0.60 (p 0.0086, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRIN3B in dopamine neurons.
case closed: nothing better to follow up.
receipt 0092: GRIN3B in dopamine neurons, resilience
- power
- full sample -0.05 (p 0.817, n 55), 95% CI -0.31 to +0.22. the interval is wide: not enough donors to tell.
- confounder
- adjusted for age, sex and PMI: -0.03 (p 0.866, n 55). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: -0.03 (p 0.883, n 55). could be the mix.
- skeptic
- leave-one-out range -0.15 to +0.05, sign flips 4; without severely affected donors -0.05 (p 0.807, n 46). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for GRIN3B in dopamine neurons.
case closed: nothing better to follow up.
receipt 0091: GRIN3B in dopamine neurons, braak
- power
- full sample +0.15 (p 0.180, n 84), 95% CI -0.07 to +0.35. the interval sits on zero: probably nothing there.
- confounder
- adjusted for age, sex and PMI: +0.13 (p 0.243, n 84). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis -0.72 (p 1.8e-14); controlling for it: +0.12 (p 0.273, n 84). could be the mix.
- skeptic
- leave-one-out range +0.12 to +0.19, sign flips 0; without severely affected donors +0.17 (p 0.156, n 75). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRIN3B in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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