Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.60 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in brain inhibitory neurons (108 nCPM) | 1.00 |
| chemistry Open Targets | compounds already reach it: acamprosate calcium, gw468816, acamprosate +24 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 1 stopped | 0.20 |
| literature PubMed | 1 Parkinson's papers of 98 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11454
Earlier readings: 2026-10-26 0.51; 2026-10-25 0.51; 2026-10-24 0.51; 2026-10-23 0.51.
Sealed predictions
- GRIN3A in dopamine neurons, braak+0.29 (p 0.451) → +0.27 (p 0.474)receipt 0561
- GRIN3A in dopamine neurons, braak+0.10 (p 0.518) → -0.25 (p 0.115)receipt 0088
- GRIN3A in dopamine neurons, resilience-0.16 (p 0.567) → +0.06 (p 0.846)receipt 0089
Swarm cases
receipt 0561: GRIN3A in dopamine neurons, braak
- power
- full sample +0.20 (p 0.434, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.18 (p 0.487, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.25 (p 0.315, n 18). could be the mix.
- skeptic
- leave-one-out range +0.07 to +0.36, sign flips 0; without severely affected donors +0.20 (p 0.434, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRIN3A in dopamine neurons.
case closed: nothing better to follow up.
receipt 0089: GRIN3A in dopamine neurons, resilience
- power
- full sample -0.10 (p 0.599, n 55), 95% CI -0.36 to +0.17. the interval is wide: not enough donors to tell.
- confounder
- adjusted for age, sex and PMI: -0.14 (p 0.474, n 55). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: -0.14 (p 0.487, n 55). could be the mix.
- skeptic
- leave-one-out range -0.20 to -0.01, sign flips 0; without severely affected donors -0.17 (p 0.388, n 46). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for GRIN3A in dopamine neurons.
case closed: nothing better to follow up.
receipt 0088: GRIN3A in dopamine neurons, braak
- power
- full sample -0.05 (p 0.637, n 84), 95% CI -0.26 to +0.16. the interval sits on zero: probably nothing there.
- confounder
- adjusted for age, sex and PMI: -0.06 (p 0.597, n 84). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis -0.72 (p 1.8e-14); controlling for it: -0.07 (p 0.555, n 84). could be the mix.
- skeptic
- leave-one-out range -0.09 to -0.02, sign flips 0; without severely affected donors +0.00 (p 0.986, n 75). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GRIN3A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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