Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

GAL3ST1

galactose-3-O-sulfotransferase 1

translation score 0.50, read 2026-10-20; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.06 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced in oligodendrocytes (71 nCPM)1.00
chemistry
Open Targets		reachable by antibody0.45
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		Reactome did not answer (Reactome: The operation was aborted due to timeout)0.00

No case: the score is under the bar. Receipt 4318

Sealed predictions

  1. GAL3ST1 in oligodendrocytes, braak-0.66 (p 0.053) → -0.42 (p 0.266)receipt 4325
  2. GAL3ST1 in dopamine neurons, braak-0.30 (p 0.430) → -0.29 (p 0.457)receipt 4326

Swarm cases

receipt 4326: GAL3ST1 in dopamine neurons, braak

power
full sample -0.35 (p 0.153, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.34 (p 0.167, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.095, n 18). could be the mix.
skeptic
leave-one-out range -0.47 to -0.27, sign flips 0; without severely affected donors -0.35 (p 0.153, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GAL3ST1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4325: GAL3ST1 in oligodendrocytes, braak

power
full sample -0.51 (p 0.032, n 18), 95% CI -0.79 to -0.05. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.45 (p 0.063, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.49 (p 0.039, n 18). not the mix.
skeptic
leave-one-out range -0.64 to -0.44, sign flips 0; without severely affected donors -0.51 (p 0.032, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GAL3ST1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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