parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.15 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in hematopoietic stem cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 263	0.91
pathways Reactome	6 pathways; mostly growth signalling	0.60

No case: the score is under the bar. Receipt 2205

receipt 2215: ELMO1 in dopamine neurons, braak

power: full sample +0.18 (p 0.487, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.16 (p 0.526, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.567, n 18). could be the mix.
skeptic: leave-one-out range +0.06 to +0.31, sign flips 0; without severely affected donors +0.18 (p 0.487, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ELMO1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2214: ELMO1 in microglia, braak

power: full sample -0.14 (p 0.573, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.18 (p 0.476, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.17 (p 0.504, n 18). could be the mix.
skeptic: leave-one-out range -0.29 to -0.05, sign flips 0; without severely affected donors -0.14 (p 0.573, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ELMO1 in microglia.

case closed: nothing better to follow up.

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